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Structural role of the T94I rhodopsin mutation in congenital stationary night blindness

Congenital stationary night blindness (CSNB) is an inherited and non‐progressive retinal dysfunction. Here, we present the crystal structure of CSNB‐causing T94I(2.61) rhodopsin in the active conformation at 2.3 Å resolution. The introduced hydrophobic side chain prolongs the lifetime of the G prote...

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Détails bibliographiques
Publié dans:EMBO Rep
Auteurs principaux: Singhal, Ankita, Guo, Ying, Matkovic, Milos, Schertler, Gebhard, Deupi, Xavier, Yan, Elsa CY, Standfuss, Joerg
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5048376/
https://ncbi.nlm.nih.gov/pubmed/27458239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201642671
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