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Structural role of the T94I rhodopsin mutation in congenital stationary night blindness

Congenital stationary night blindness (CSNB) is an inherited and non‐progressive retinal dysfunction. Here, we present the crystal structure of CSNB‐causing T94I(2.61) rhodopsin in the active conformation at 2.3 Å resolution. The introduced hydrophobic side chain prolongs the lifetime of the G prote...

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書目詳細資料
發表在:EMBO Rep
Main Authors: Singhal, Ankita, Guo, Ying, Matkovic, Milos, Schertler, Gebhard, Deupi, Xavier, Yan, Elsa CY, Standfuss, Joerg
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5048376/
https://ncbi.nlm.nih.gov/pubmed/27458239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201642671
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