Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 binding

The effects of activating mutations associated with night blindness on the stoichiometry of rhodopsin interactions with G protein-coupled receptor kinase 1 (GRK1) and arrestin-1 have not been reported. Here we show that the monomeric form of WT rhodopsin and its constitutively active mutants M257Y,...

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Main Authors: Vishnivetskiy, Sergey. A., Ostermaier, Martin K., Singhal, Ankita, Panneels, Valerie, Homan, Kristoff T., Glukhova, Alisa, Sligar, Stephen G., Tesmer, John J. G., Schertler, Gebhard F.X., Standfuss, Joerg, Gurevich, Vsevolod V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774132/
https://ncbi.nlm.nih.gov/pubmed/23872075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2013.07.009
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