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GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy
Somatic hypermutation in B cells is initiated by activation-induced cytidine deaminase-catalyzed C→U deamination at immunoglobulin variable regions. Here we investigate the role of the germinal centre-associated nuclear protein (GANP) in enhancing the access of activation-induced cytidine deaminase...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Pub. Group
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3674236/ https://ncbi.nlm.nih.gov/pubmed/23652018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2823 |
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