PFI-1 – A highly Selective Protein Interaction Inhibitor Targeting BET Bromodomains

Bromo and extra terminal (BET) proteins (BRD2, BRD3, BRD4 and BRDT) are transcriptional regulators required for efficient expression of several growth promoting and anti-apoptotic genes as well as for cell cycle progression. BET proteins are recruited to transcriptionally active chromatin via their...

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Main Authors: Picaud, Sarah, Costa, David Da, Thanasopoulou, Angeliki, Filippakopoulos, Panagis, Fish, Paul V., Philpott, Martin, Fedorov, Oleg, Brennan, Paul, Bunnage, Mark E., Owen, Dafydd R., Bradner, James E., Taniere, Philippe, O’Sullivan, Brendan, Müller, Susanne, Schwaller, Juerg, Stankovic, Tatjana, Knapp, Stefan
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3673830/
https://ncbi.nlm.nih.gov/pubmed/23576556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-3292
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