PFI-1 – A highly Selective Protein Interaction Inhibitor Targeting BET Bromodomains

Bromo and extra terminal (BET) proteins (BRD2, BRD3, BRD4 and BRDT) are transcriptional regulators required for efficient expression of several growth promoting and anti-apoptotic genes as well as for cell cycle progression. BET proteins are recruited to transcriptionally active chromatin via their...

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主要な著者: Picaud, Sarah, Costa, David Da, Thanasopoulou, Angeliki, Filippakopoulos, Panagis, Fish, Paul V., Philpott, Martin, Fedorov, Oleg, Brennan, Paul, Bunnage, Mark E., Owen, Dafydd R., Bradner, James E., Taniere, Philippe, O’Sullivan, Brendan, Müller, Susanne, Schwaller, Juerg, Stankovic, Tatjana, Knapp, Stefan
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3673830/
https://ncbi.nlm.nih.gov/pubmed/23576556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-3292
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