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Integrating genealogical and dynamical modelling to infer escape and reversion rates in HIV epitopes

The rates of escape and reversion in response to selection pressure arising from the host immune system, notably the cytotoxic T-lymphocyte (CTL) response, are key factors determining the evolution of HIV. Existing methods for estimating these parameters from cross-sectional population data using or...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Palmer, Duncan, Frater, John, Phillips, Rodney, McLean, Angela R., McVean, Gil
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Royal Society 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3673055/
https://ncbi.nlm.nih.gov/pubmed/23677344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rspb.2013.0696
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