Cytotoxic T-Lymphocyte Escape Mutations Identified by HLA Association Favor Those Which Escape and Revert Rapidly

Identifying human immunodeficiency virus (HIV) immune escape mutations has implications for understanding the impact of host immunity on pathogen evolution and guiding the choice of vaccine antigens. One means of identifying cytotoxic-T-lymphocyte (CTL) escape mutations is to search for statistical...

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Bibliographic Details
Main Authors: Fryer, Helen R., Frater, John, Duda, Anna, Palmer, Duncan, Phillips, Rodney E., McLean, Angela R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Genetic Diversity and Evolution
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421756/
https://ncbi.nlm.nih.gov/pubmed/22674992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07020-11
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