The Ataxia Telangiectasia Mutated Kinase pathway Regulates IL-23 Expression by Human Dendritic Cells

Little is known of the regulation of interleukin-23 secretion in dendritic cells (DC) despite its importance for human Th17 responses. Here we show for first time that the Ataxia Telangiectasia Mutated (ATM) pathway, involved in DNA-damage-sensing, acts as an IL-23 repressor. Inhibition of ATM with...

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Main Authors: Wang, Qunwei, Franks, Hester A, Foan, Stephanie, Refaee, Mohamed El, Malecka, Anna, Shah, Sabaria, Spendlove, Ian, Gough, Michael J, Seedhouse, Claire, Madhusudan, Srinivasan, Patel, Poulam M, Jackson, Andrew M
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672964/
https://ncbi.nlm.nih.gov/pubmed/23460736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201484
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