Novel function for the p38-MK2 signaling pathway in circulating CD1c+ (BDCA-1+) myeloid dendritic cells from healthy donors and advanced cancer patients; inhibition of p38 enhances IL-12 whilst suppressing IL-10

There is growing interest in myeloid (my) dendritic cells (DC) as an alternative to monocyte-derived DC (moDC) for immunotherapy. However, in contrast to moDC, little is known regarding the effect of malignancy on the function, abundance or use of intracellular signaling pathways in myDC. Understand...

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Detalles Bibliográficos
Publicado en:Int J Cancer
Main Authors: Franks, Hester A, Wang, Qunwei, Lax, Stephanie J, Collins, Mary K, Escors, David, Patel, Poulam M, Jackson, Andrew M
Formato: Artigo
Idioma:Inglês
Publicado: BlackWell Publishing Ltd 2014
Assuntos:
Tumor Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298783/
https://ncbi.nlm.nih.gov/pubmed/23901045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.28398
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