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Crystal structure of Prp8 reveals active site cavity of the spliceosome
The active centre of the spliceosome consists of an intricate network formed by U5, U2 and U6 snRNAs, and a pre-mRNA substrate. Prp8, a component of the U5 snRNP, crosslinks extensively with this RNA catalytic core. We present the crystal structure of yeast Prp8 (residues 885-2413) in complex with t...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3672837/ https://ncbi.nlm.nih.gov/pubmed/23354046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11843 |
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