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Structural studies of the spliceosome: zooming into the heart of the machine()

Spliceosomes are large, dynamic ribonucleoprotein complexes that catalyse the removal of introns from messenger RNA precursors via a two-step splicing reaction. The recent crystal structure of Prp8 has revealed Reverse Transcriptase-like, Linker and Endonuclease-like domains. The intron branch-point...

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Autori principali: Galej, Wojciech P, Nguyen, Thi Hoang Duong, Newman, Andrew J, Nagai, Kiyoshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier Science 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4045393/
https://ncbi.nlm.nih.gov/pubmed/24480332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2013.12.002
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