SH2B3 (LNK) mutations from Myeloproliferative Neoplasms patients have mild loss of function against wild type JAK2 and JAK2 V617F

Somatic point mutations in the PH domain of SH2B3 (LNK), an adaptor protein that is highly expressed in haematopoietic cells, were recently described in patients with myeloproliferative neoplasms. We studied the effect of these mutations on the JAK2 signalling pathway in cells expressing either wild...

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Bibliographic Details
Main Authors: Koren-Michowitz, Maya, Gery, Sigal, Tabayashi, Takayuki, Lin, Dechen, Alvarez, Rocio, Nagler, Arnon, Koeffler, H. Phillip
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672250/
https://ncbi.nlm.nih.gov/pubmed/23590807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.12327
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