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Conformational templating of α-synuclein aggregates in neuronal-glial cultures

BACKGROUND: Genetic studies have established a causative role for α-synuclein (αS) in Parkinson’s disease (PD), and the presence of αS aggregates in the form of Lewy body (LB) and Lewy neurite (LN) protein inclusions are defining pathological features of PD. Recent data has established that extracel...

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Detalhes bibliográficos
Main Authors: Sacino, Amanda N, Thomas, Michael A, Ceballos-Diaz, Carolina, Cruz, Pedro E, Rosario, Awilda M, Lewis, Jada, Giasson, Benoit I, Golde, Todd E
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671973/
https://ncbi.nlm.nih.gov/pubmed/23714769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-8-17
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