SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia

Global increases in small ubiquitin-like modifier (SUMO)-2/3 conjugation are a neuroprotective response to severe stress but the mechanisms and specific target proteins that determine cell survival have not been identified. Here, we demonstrate that the SUMO-2/3-specific protease SENP3 is degraded d...

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Bibliografiske detaljer
Main Authors: Guo, Chun, Hildick, Keri L, Luo, Jia, Dearden, Laura, Wilkinson, Kevin A, Henley, Jeremy M
Format: Artigo
Sprog:Inglês
Udgivet: European Molecular Biology Organization 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671254/
https://ncbi.nlm.nih.gov/pubmed/23524851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.65
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