SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death

The GTPase dynamin-related protein 1 (Drp1) is essential for physiological and pathophysiological mitochondrial fission. DeSUMOylation of Drp1 by the enzyme SENP3 promotes cell death during reperfusion after ischaemia by enhancing Drp1 partitioning to the mitochondrial outer membrane (MOM), which ca...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Guo, Chun, Wilkinson, Kevin A., Evans, Ashley J., Rubin, Philip P., Henley, Jeremy M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338345/
https://ncbi.nlm.nih.gov/pubmed/28262828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43811
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