Enhanced SUMOylation and SENP-1 protein levels following oxygen and glucose deprivation in neurones

Here, we show that oxygen and glucose deprivation (OGD) causes increased small ubiquitin-like modifier (SUMO)-1 and SUMO-2/3 conjugation to substrate proteins in cultured hippocampal neurones. Surprisingly, the SUMO protease SENP-1, which removes SUMO from conjugated proteins, was also increased by...

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Detalhes bibliográficos
Main Authors: Cimarosti, Helena, Ashikaga, Emi, Jaafari, Nadia, Dearden, Laura, Rubin, Philip, Wilkinson, Kevin A, Henley, Jeremy M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308141/
https://ncbi.nlm.nih.gov/pubmed/21989481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.146
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