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SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death

The GTPase dynamin-related protein 1 (Drp1) is essential for physiological and pathophysiological mitochondrial fission. DeSUMOylation of Drp1 by the enzyme SENP3 promotes cell death during reperfusion after ischaemia by enhancing Drp1 partitioning to the mitochondrial outer membrane (MOM), which ca...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Guo, Chun, Wilkinson, Kevin A., Evans, Ashley J., Rubin, Philip P., Henley, Jeremy M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338345/
https://ncbi.nlm.nih.gov/pubmed/28262828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43811
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