Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs

Cystic fibrosis (CF) pigs develop disease with features remarkably similar to those in people with CF, including exocrine pancreatic destruction, focal biliary cirrhosis, micro-gallbladder, vas deferens loss, airway disease, and meconium ileus. Whereas meconium ileus occurs in 15% of babies with CF,...

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Autores principales: Stoltz, David A., Rokhlina, Tatiana, Ernst, Sarah E., Pezzulo, Alejandro A., Ostedgaard, Lynda S., Karp, Philip H., Samuel, Melissa S., Reznikov, Leah R., Rector, Michael V., Gansemer, Nicholas D., Bouzek, Drake C., Alaiwa, Mahmoud H. Abou, Hoegger, Mark J., Ludwig, Paula S., Taft, Peter J., Wallen, Tanner J., Wohlford-Lenane, Christine, McMenimen, James D., Chen, Jeng-Haur, Bogan, Katrina L., Adam, Ryan J., Hornick, Emma E., Nelson, George A., Hoffman, Eric A., Chang, Eugene H., Zabner, Joseph, McCray, Paul B., Prather, Randall S., Meyerholz, David K., Welsh, Michael J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2013
Materias:
Technical Advance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668832/
https://ncbi.nlm.nih.gov/pubmed/23676501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI68867
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