The ΔF508 Mutation Causes CFTR Misprocessing and Cystic Fibrosis-Like Disease in Pigs

Mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel cause the autosomal recessive disease, cystic fibrosis (CF). The most common mutation is ΔF508, which deletes phenylalanine508. In vitro studies indicate that CFTR-ΔF508 is misprocessed, thoug...

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Huvudupphovsmän: Ostedgaard, Lynda S, Meyerholz, David K, Chen, Jeng-Haur, Pezzulo, Alejandro A, Karp, Philip H, Rokhlina, Tatiana, Ernst, Sarah E, Hanfland, Robert A, Reznikov, Leah R, Ludwig, Paula S, Rogan, Mark P, Davis, Greg J, Dohrn, Cassie L, Wohlford-Lenane, Christine, Taft, Peter J, Rector, Michael V, Hornick, Emma, Nassar, Boulos S, Samuel, Melissa, Zhang, Yuping, Richter, Sandra S, Uc, Aliye, Shilyansky, Joel, Prather, Randall S, McCray, Paul B, Zabner, Joseph, Welsh, Michael J, Stoltz, David A
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119077/
https://ncbi.nlm.nih.gov/pubmed/21411740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3001868
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