Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs

Cystic fibrosis (CF) pigs develop disease with features remarkably similar to those in people with CF, including exocrine pancreatic destruction, focal biliary cirrhosis, micro-gallbladder, vas deferens loss, airway disease, and meconium ileus. Whereas meconium ileus occurs in 15% of babies with CF,...

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Hauptverfasser: Stoltz, David A., Rokhlina, Tatiana, Ernst, Sarah E., Pezzulo, Alejandro A., Ostedgaard, Lynda S., Karp, Philip H., Samuel, Melissa S., Reznikov, Leah R., Rector, Michael V., Gansemer, Nicholas D., Bouzek, Drake C., Alaiwa, Mahmoud H. Abou, Hoegger, Mark J., Ludwig, Paula S., Taft, Peter J., Wallen, Tanner J., Wohlford-Lenane, Christine, McMenimen, James D., Chen, Jeng-Haur, Bogan, Katrina L., Adam, Ryan J., Hornick, Emma E., Nelson, George A., Hoffman, Eric A., Chang, Eugene H., Zabner, Joseph, McCray, Paul B., Prather, Randall S., Meyerholz, David K., Welsh, Michael J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2013
Schlagworte:
Technical Advance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668832/
https://ncbi.nlm.nih.gov/pubmed/23676501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI68867
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