Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium

TNF has remarkable antitumor activities; however, therapeutic applications have not been possible because of the systemic and lethal proinflammatory effects induced by TNF. Both the antitumor and inflammatory effects of TNF are mediated by the TNF receptor p55 (p55TNFR) (encoded by the Tnfrsf1a gene...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Van Hauwermeiren, Filip, Armaka, Marietta, Karagianni, Niki, Kranidioti, Ksanthi, Vandenbroucke, Roosmarijn E., Loges, Sonja, Van Roy, Maarten, Staelens, Jan, Puimège, Leen, Palagani, Ajay, Berghe, Wim Vanden, Victoratos, Panayiotis, Carmeliet, Peter, Libert, Claude, Kollias, George
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2013
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668821/
https://ncbi.nlm.nih.gov/pubmed/23676465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65624
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