Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium

TNF has remarkable antitumor activities; however, therapeutic applications have not been possible because of the systemic and lethal proinflammatory effects induced by TNF. Both the antitumor and inflammatory effects of TNF are mediated by the TNF receptor p55 (p55TNFR) (encoded by the Tnfrsf1a gene...

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Détails bibliographiques
Auteurs principaux: Van Hauwermeiren, Filip, Armaka, Marietta, Karagianni, Niki, Kranidioti, Ksanthi, Vandenbroucke, Roosmarijn E., Loges, Sonja, Van Roy, Maarten, Staelens, Jan, Puimège, Leen, Palagani, Ajay, Berghe, Wim Vanden, Victoratos, Panayiotis, Carmeliet, Peter, Libert, Claude, Kollias, George
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668821/
https://ncbi.nlm.nih.gov/pubmed/23676465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65624
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