Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium

TNF has remarkable antitumor activities; however, therapeutic applications have not been possible because of the systemic and lethal proinflammatory effects induced by TNF. Both the antitumor and inflammatory effects of TNF are mediated by the TNF receptor p55 (p55TNFR) (encoded by the Tnfrsf1a gene...

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Autores principales: Van Hauwermeiren, Filip, Armaka, Marietta, Karagianni, Niki, Kranidioti, Ksanthi, Vandenbroucke, Roosmarijn E., Loges, Sonja, Van Roy, Maarten, Staelens, Jan, Puimège, Leen, Palagani, Ajay, Berghe, Wim Vanden, Victoratos, Panayiotis, Carmeliet, Peter, Libert, Claude, Kollias, George
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668821/
https://ncbi.nlm.nih.gov/pubmed/23676465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65624
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