Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib

BACKGROUND: Dichloroacetate (DCA), through the inhibition of aerobic glycolysis (the ‘Warburg effect') and promotion of pyruvate oxidation, induces growth reduction in many tumours and is now undergoing several clinical trials. If aerobic glycolysis is active in multiple myeloma (MM) cells, it...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Sanchez, W Y, McGee, S L, Connor, T, Mottram, B, Wilkinson, A, Whitehead, J P, Vuckovic, S, Catley, L
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2013
Gaiak:
Translational Therapeutics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668464/
https://ncbi.nlm.nih.gov/pubmed/23531700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.120
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