Differential downregulation of telomerase activity by bortezomib in multiple myeloma cells-multiple regulatory pathways in vitro and ex vivo

BACKGROUND: The importance of telomerase in multiple myeloma (MM) is well established; however, its response to bortezomib has not been addressed. METHODS: The effect of bortezomib on telomerase activity and cell proliferation was evaluated in four MM cell lines and in myeloma cells obtained from ei...

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Detalhes bibliográficos
Main Authors: Weiss, C, Uziel, O, Wolach, O, Nordenberg, J, Beery, E, Bulvick, S, Kanfer, G, Cohen, O, Ram, R, Bakhanashvili, M, Magen-Nativ, H, Shilo, N, Lahav, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504947/
https://ncbi.nlm.nih.gov/pubmed/23169337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.460
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