Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib

BACKGROUND: Dichloroacetate (DCA), through the inhibition of aerobic glycolysis (the ‘Warburg effect') and promotion of pyruvate oxidation, induces growth reduction in many tumours and is now undergoing several clinical trials. If aerobic glycolysis is active in multiple myeloma (MM) cells, it...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sanchez, W Y, McGee, S L, Connor, T, Mottram, B, Wilkinson, A, Whitehead, J P, Vuckovic, S, Catley, L
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2013
Pynciau:
Translational Therapeutics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668464/
https://ncbi.nlm.nih.gov/pubmed/23531700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.120
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