Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib

BACKGROUND: Dichloroacetate (DCA), through the inhibition of aerobic glycolysis (the ‘Warburg effect') and promotion of pyruvate oxidation, induces growth reduction in many tumours and is now undergoing several clinical trials. If aerobic glycolysis is active in multiple myeloma (MM) cells, it...

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Hlavní autoři: Sanchez, W Y, McGee, S L, Connor, T, Mottram, B, Wilkinson, A, Whitehead, J P, Vuckovic, S, Catley, L
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
Témata:
Translational Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668464/
https://ncbi.nlm.nih.gov/pubmed/23531700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.120
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