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The basic principles of chimeric antigen receptor (CAR) design

CARs are recombinant receptors that provide both antigen-binding and T cell activating functions. A multitude of CARs has been reported over the past decade, targeting an array of cell surface tumor antigens. Their biological functions have dramatically changed following the introduction of tri-part...

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Autores principales: Sadelain, Michel, Brentjens, Renier, Riviere, Isabelle
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3667586/
https://ncbi.nlm.nih.gov/pubmed/23550147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0548
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