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Hierarchical Organization of Multi-Site Phosphorylation at the CXCR4 C Terminus

The chemokine receptor CXCR4 regulates cell migration during ontogenesis and disease states including cancer and inflammation. Upon stimulation by the endogenous ligand CXCL12, CXCR4 becomes phosphorylated at multiple sites in its C-terminal domain. Mutations in the CXCR4 gene affecting C-terminal p...

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Detalhes bibliográficos
Main Authors: Mueller, Wiebke, Schütz, Dagmar, Nagel, Falko, Schulz, Stefan, Stumm, Ralf
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3666969/
https://ncbi.nlm.nih.gov/pubmed/23734232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064975
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