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Rapid Uptake and Degradation of CXCL12 Depend on CXCR7 Carboxyl-terminal Serine/Threonine Residues

CXCL12 signaling through G protein-coupled CXCR4 regulates cell migration during ontogenesis and disease states including cancer and inflammation. The second CXCL12-receptor CXCR7 modulates the CXCL12/CXCR4 pathway by acting as a CXCL12 scavenger and exerts G protein-independent functions. Given the...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Hoffmann, Frauke, Müller, Wiebke, Schütz, Dagmar, Penfold, Mark E., Wong, Yung H., Schulz, Stefan, Stumm, Ralf
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436560/
https://ncbi.nlm.nih.gov/pubmed/22736769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.335679
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