Differentiation of Opioid Drug Effects by Hierarchical Multi-Site Phosphorylation

Differences in the ability of opioid drugs to promote regulated endocytosis of μ-opioid receptors are related to their tendency to produce drug tolerance and dependence. Here we show that drug-specific differences in receptor internalization are determined by a conserved, 10-residue sequence in the...

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Main Authors: Just, Sascha, Illing, Susann, Trester-Zedlitz, Michelle, Lau, Elaine K., Kotowski, Sarah J., Miess, Elke, Mann, Anika, Doll, Christian, Trinidad, Jonathan C., Burlingame, Alma L., von Zastrow, Mark, Schulz, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583494/
https://ncbi.nlm.nih.gov/pubmed/23239825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.082875
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