Analgesic Tolerance to High-Efficacy Agonists But Not to Morphine Is Diminished in Phosphorylation-Deficient S375A μ-Opioid Receptor Knock-In Mice

Morphine is one of the most potent analgesic drugs. However, the utility of morphine in the management of chronic pain is limited by its rapid development of tolerance. Morphine exerts all of its pharmacological effects via the μ-opioid receptor. In many systems, tolerance is associated with phospho...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Grecksch, Gisela, Just, Sascha, Pierstorff, Claudia, Imhof, Anne-Katja, Glück, Laura, Doll, Christian, Lupp, Amelie, Becker, Axel, Koch, Thomas, Stumm, Ralf, Höllt, Volker, Schulz, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633166/
https://ncbi.nlm.nih.gov/pubmed/21957251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2304-11.2011
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