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Morphine induces terminal μ-opioid receptor desensitization by sustained phosphorylation of serine-375
Morphine is a poor inducer of μ-opioid receptor (MOR) internalization, but a potent inducer of cellular tolerance. Here we show that, in contrast to full agonists such as [D-Ala(2)-MePhe(4)-Gly-ol]enkephalin (DAMGO), morphine stimulated a selective phosphorylation of the carboxy-terminal residue 375...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC514508/ https://ncbi.nlm.nih.gov/pubmed/15272312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600334 |
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