Morphine induces terminal μ-opioid receptor desensitization by sustained phosphorylation of serine-375

Morphine is a poor inducer of μ-opioid receptor (MOR) internalization, but a potent inducer of cellular tolerance. Here we show that, in contrast to full agonists such as [D-Ala(2)-MePhe(4)-Gly-ol]enkephalin (DAMGO), morphine stimulated a selective phosphorylation of the carboxy-terminal residue 375...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Schulz, Stefan, Mayer, Dana, Pfeiffer, Manuela, Stumm, Ralf, Koch, Thomas, Höllt, Volker
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2004
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC514508/
https://ncbi.nlm.nih.gov/pubmed/15272312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600334
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