Regulation of µ-Opioid Receptors: Desensitization, Phosphorylation, Internalization, and Tolerance

Morphine and related µ-opioid receptor (MOR) agonists remain among the most effective drugs known for acute relief of severe pain. A major problem in treating painful conditions is that tolerance limits the long-term utility of opioid agonists. Considerable effort has been expended on developing an...

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Detalhes bibliográficos
Main Authors: Williams, John T., Ingram, Susan L., Henderson, Graeme, Chavkin, Charles, von Zastrow, Mark, Schulz, Stefan, Koch, Thomas, Evans, Christopher J., Christie, MacDonald J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
Assuntos:
Review Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565916/
https://ncbi.nlm.nih.gov/pubmed/23321159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/pr.112.005942
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