Two Distinct Mechanisms Mediate Acute μ-Opioid Receptor Desensitization in Native Neurons

Sustained stimulation of G-protein coupled receptors (GPCRs) leads to rapid loss of receptor function (acute desensitization). For many GPCRs including the μ-opioid receptor (MOR), an accepted mechanism for acute desensitization is through G-protein coupled receptor kinase (GRKs) mediated phosphoryl...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Dang, Vu C., Napier, Ian A., Christie, MacDonald J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6666456/
https://ncbi.nlm.nih.gov/pubmed/19279269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4749-08.2009
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