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μ-Opioid receptor activation and noradrenaline transport inhibition by tapentadol in rat single locus coeruleus neurons
BACKGROUND AND PURPOSE: Tapentadol is a novel analgesic that combines moderate μ-opioid receptor agonism and noradrenaline reuptake inhibition in a single molecule. Both mechanisms of action are involved in producing analgesia; however, the potency and efficacy of tapentadol in individual neurons ha...
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| Publicado en: | Br J Pharmacol |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Blackwell Publishing Ltd
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4292960/ https://ncbi.nlm.nih.gov/pubmed/24372103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12566 |
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