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μ-Opioid receptor activation and noradrenaline transport inhibition by tapentadol in rat single locus coeruleus neurons
BACKGROUND AND PURPOSE: Tapentadol is a novel analgesic that combines moderate μ-opioid receptor agonism and noradrenaline reuptake inhibition in a single molecule. Both mechanisms of action are involved in producing analgesia; however, the potency and efficacy of tapentadol in individual neurons ha...
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| 發表在: | Br J Pharmacol |
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| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Blackwell Publishing Ltd
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4292960/ https://ncbi.nlm.nih.gov/pubmed/24372103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12566 |
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