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Cellular Morphine Tolerance Produced by βArrestin-2-Dependent Impairment of μ-Opioid Receptor Resensitization

Chronic morphine treatment produces behavioral and cellular opioid tolerance that has been proposed to be caused by attenuated μ-opioid receptor (MOR) recovery from desensitization (resensitization). The process of MOR resensitization is thought to require βarrestin-2 (βarr-2)-dependent trafficking...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Dang, Vu C., Chieng, Billy, Azriel, Yael, Christie, MacDonald J.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703228/
https://ncbi.nlm.nih.gov/pubmed/21562274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5999-10.2011
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