CD2AP/SHIP1 Complex Positively Regulates Plasmacytoid Dendritic Cell Receptor Signaling by Inhibiting the E3 Ubiquitin Ligase Cbl

The human plasmacytoid dendritic cell (pDC) receptor BDCA2 forms a complex with the adaptor FcεR1γ to activate an ITAM-signaling cascade. BDCA2 receptor signaling negatively regulates the TLR7/9-mediated type 1 IFN responses in pDCs, which may play a key role in controlling self-DNA/RNA–induced auto...

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Main Authors: Bao, Musheng, Hanabuchi, Shino, Facchinetti, Valeria, Du, Qiumei, Bover, Laura, Plumas, Joel, Chaperot, Laurence, Cao, Wei, Qin, Jun, Sun, Shao-Cong, Liu, Yong-Jun
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3665352/
https://ncbi.nlm.nih.gov/pubmed/22706086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200887
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