Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses

Host cellular endoplasmic reticulum α-glucosidases I and II are essential for the maturation of viral glycosylated envelope proteins that use the calnexin mediated folding pathway. Inhibition of these glycan processing enzymes leads to the misfolding and degradation of these viral glycoproteins and...

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Autors principals: Chang, Jinhong, Warren, Travis K., Zhao, Xuesen, Gill, Tina, Guo, Fang, Wang, Lijuan, Comunale, Mary Ann, Du, Yanming, Alonzi, Dominic S., Yu, Wenquan, Ye, Hong, Liu, Fei, Guo, Ju-Tao, Mehta, Anand, Cuconati, Andrea, Butters, Terry D., Bavari, Sina, Xu, Xiaodong, Block, Timothy M.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663898/
https://ncbi.nlm.nih.gov/pubmed/23578725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2013.03.023
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