Inhibition of Endoplasmic Reticulum-Resident Glucosidases Impairs Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63 Spike Protein-Mediated Entry by Altering the Glycan Processing of Angiotensin I-Converting Enzyme 2

Endoplasmic reticulum (ER)-resident glucosidases I and II sequentially trim the three terminal glucose moieties on the N-linked glycans attached to nascent glycoproteins. These reactions are the first steps of N-linked glycan processing and are essential for proper folding and function of many glyco...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Zhao, Xuesen, Guo, Fang, Comunale, Mary Ann, Mehta, Anand, Sehgal, Mohit, Jain, Pooja, Cuconati, Andrea, Lin, Hanxin, Block, Timothy M., Chang, Jinhong, Guo, Ju-Tao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291352/
https://ncbi.nlm.nih.gov/pubmed/25348530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03999-14
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