Design, Synthesis, and Biological Evaluation of N-Alkylated Deoxynojirimycin (DNJ) Derivatives for the Treatment of Dengue Virus Infection

We recently described the discovery of oxygenated N-alkyl deoxynojirimycin (DNJ) derivative 7 (CM-10-18) with antiviral activity against dengue virus (DENV) infection both in vitro and in vivo. This imino sugar was promising, but had an EC(50) against DENV in BHK cells of 6.5 μM, which limited its u...

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Bibliografiske detaljer
Main Authors: Yu, Wenquan, Gill, Tina, Wang, Lijuan, Du, Yanming, Ye, Hong, Qu, Xiaowang, Guo, Ju-Tao, Cuconati, Andrea, Zhao, Kang, Block, Timothy M., Xu, Xiaodong, Chang, Jinhong
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395807/
https://ncbi.nlm.nih.gov/pubmed/22712544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300171v
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