Design, Synthesis, and Biological Evaluation of N-Alkylated Deoxynojirimycin (DNJ) Derivatives for the Treatment of Dengue Virus Infection

We recently described the discovery of oxygenated N-alkyl deoxynojirimycin (DNJ) derivative 7 (CM-10-18) with antiviral activity against dengue virus (DENV) infection both in vitro and in vivo. This imino sugar was promising, but had an EC(50) against DENV in BHK cells of 6.5 μM, which limited its u...

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Huvudupphovsmän: Yu, Wenquan, Gill, Tina, Wang, Lijuan, Du, Yanming, Ye, Hong, Qu, Xiaowang, Guo, Ju-Tao, Cuconati, Andrea, Zhao, Kang, Block, Timothy M., Xu, Xiaodong, Chang, Jinhong
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395807/
https://ncbi.nlm.nih.gov/pubmed/22712544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300171v
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