Preparation, biochemical characterization and biological properties of radiolabelled N-alkylated deoxynojirimycins.

We have reductively alkylated deoxynojirimycin imino sugars using sodium cyanoborohydride to provide an efficient means of generating a series of N-alkylated compounds containing 4-18 carbon side chains. The yields were greater than 90% using a variety of aldehydes of different chain lengths, and af...

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Detalhes bibliográficos
Main Authors: Mellor, Howard R, Nolan, James, Pickering, Lea, Wormald, Mark R, Platt, Frances M, Dwek, Raymond A, Fleet, George W J, Butters, Terry D
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222746/
https://ncbi.nlm.nih.gov/pubmed/11982484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020466
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