Membrane disruption and cytotoxicity of hydrophobic N-alkylated imino sugars is independent of the inhibition of protein and lipid glycosylation.

The N-alkyl moiety of N-alkylated imino sugars is crucial for therapeutic activities of these compounds as inhibitors of glycosphingolipid (GSL) biosynthesis and as antivirals. The improved potency afforded by a long N-alkyl moiety is coincident with increased compound-induced cytotoxicity. Therefor...

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Bibliografiska uppgifter
Huvudupphovsmän: Mellor, Howard R, Platt, Frances M, Dwek, Raymond A, Butters, Terry D
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2003
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223602/
https://ncbi.nlm.nih.gov/pubmed/12769816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030348
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