High Error Rates in Selenocysteine Insertion in Mammalian Cells Treated with the Antibiotic Doxycycline, Chloramphenicol, or Geneticin

Antibiotics target bacteria by interfering with essential processes such as translation, but their effects on translation in mammalian cells are less well characterized. We found that doxycycline, chloramphenicol, and Geneticin (G418) interfered with insertion of selenocysteine (Sec), which is encod...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Tobe, Ryuta, Naranjo-Suarez, Salvador, Everley, Robert A., Carlson, Bradley A., Turanov, Anton A., Tsuji, Petra A., Yoo, Min-Hyuk, Gygi, Steven P., Gladyshev, Vadim N., Hatfield, Dolph L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663496/
https://ncbi.nlm.nih.gov/pubmed/23589299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.446666
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi