Targeted insertion of cysteine by decoding UGA codons with mammalian selenocysteine machinery

Cysteine (Cys) is inserted into proteins in response to UGC and UGU codons. Herein, we show that supplementation of mammalian cells with thiophosphate led to targeted insertion of Cys at the UGA codon of thioredoxin reductase 1 (TR1). This Cys was synthesized by selenocysteine (Sec) synthase on tRNA...

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Detalhes bibliográficos
Main Authors: Xu, Xue-Ming, Turanov, Anton A., Carlson, Bradley A., Yoo, Min-Hyuk, Everley, Robert A., Nandakumar, Renu, Sorokina, Irina, Gygi, Steven P., Gladyshev, Vadim N., Hatfield, Dolph L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003055/
https://ncbi.nlm.nih.gov/pubmed/21115847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009947107
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