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Targeted insertion of cysteine by decoding UGA codons with mammalian selenocysteine machinery
Cysteine (Cys) is inserted into proteins in response to UGC and UGU codons. Herein, we show that supplementation of mammalian cells with thiophosphate led to targeted insertion of Cys at the UGA codon of thioredoxin reductase 1 (TR1). This Cys was synthesized by selenocysteine (Sec) synthase on tRNA...
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| Hlavní autoři: | , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3003055/ https://ncbi.nlm.nih.gov/pubmed/21115847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009947107 |
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