UGA codon position-dependent incorporation of selenocysteine into mammalian selenoproteins

It is thought that the SelenoCysteine Insertion Sequence (SECIS) element and UGA codon are sufficient for selenocysteine (Sec) insertion. However, we found that UGA supported Sec insertion only at its natural position or in its close proximity in mammalian thioredoxin reductase 1 (TR1). In contrast,...

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Bibliographic Details
Main Authors: Turanov, Anton A., Lobanov, Alexei V., Hatfield, Dolph L., Gladyshev, Vadim N.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737529/
https://ncbi.nlm.nih.gov/pubmed/23716634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt409
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