Targeted insertion of cysteine by decoding UGA codons with mammalian selenocysteine machinery

Cysteine (Cys) is inserted into proteins in response to UGC and UGU codons. Herein, we show that supplementation of mammalian cells with thiophosphate led to targeted insertion of Cys at the UGA codon of thioredoxin reductase 1 (TR1). This Cys was synthesized by selenocysteine (Sec) synthase on tRNA...

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書誌詳細
主要な著者: Xu, Xue-Ming, Turanov, Anton A., Carlson, Bradley A., Yoo, Min-Hyuk, Everley, Robert A., Nandakumar, Renu, Sorokina, Irina, Gygi, Steven P., Gladyshev, Vadim N., Hatfield, Dolph L.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2010
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003055/
https://ncbi.nlm.nih.gov/pubmed/21115847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009947107
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