Translational Redefinition of UGA Codons Is Regulated by Selenium Availability

Incorporation of selenium into ∼25 mammalian selenoproteins occurs by translational recoding whereby in-frame UGA codons are redefined to encode the selenium containing amino acid, selenocysteine (Sec). Here we applied ribosome profiling to examine the effect of dietary selenium levels on the transl...

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Hauptverfasser: Howard, Michael T., Carlson, Bradley A., Anderson, Christine B., Hatfield, Dolph L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Protein Synthesis and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707644/
https://ncbi.nlm.nih.gov/pubmed/23696641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.481051
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