High Error Rates in Selenocysteine Insertion in Mammalian Cells Treated with the Antibiotic Doxycycline, Chloramphenicol, or Geneticin

Antibiotics target bacteria by interfering with essential processes such as translation, but their effects on translation in mammalian cells are less well characterized. We found that doxycycline, chloramphenicol, and Geneticin (G418) interfered with insertion of selenocysteine (Sec), which is encod...

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Detalhes bibliográficos
Main Authors: Tobe, Ryuta, Naranjo-Suarez, Salvador, Everley, Robert A., Carlson, Bradley A., Turanov, Anton A., Tsuji, Petra A., Yoo, Min-Hyuk, Gygi, Steven P., Gladyshev, Vadim N., Hatfield, Dolph L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663496/
https://ncbi.nlm.nih.gov/pubmed/23589299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.446666
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